Methods for Estimating Personal Disease Risk and Phylogenetic Diversity of Hematopoietic Stem Cells

Molecular Biology and Evolution | 41:msad279 (11 pp)

J.M. Craig, G.S. Gerhard, S. Sharma, A. Yankovskiy, S. Miura, S. Kumar


Of Phylogenies and Tumors: Cancer as a Model System to Teach Evolution

The American Biology Teacher | 86:62–70 (9 pp)

C. Babaian, S. Kumar


Analyses of Allele Age and Fitness Impact Reveal Human Beneficial Alleles to be Older than Neutral Controls


A. Pivirotto, A. Platt, R. Patel, S. Kumar, J. Hey


Split-Transformer Impute (STI): A Transformer Framework for Genotype Imputation

bioRxiv | (available)

M.E. Mowlaei, C. Li, O. Jamialahmadi, R. Dias, J. Chen, B. Jamialahmadi, T.R. Rebbeck, V. Carnevale, S. Kumar, X. Shi


Evolutionary Sparse Learning Reveals the Shared Genetic Basis of Convergent Traits

| (submitted)

J. Allard , S. Sharma , R. Patel , M. Sanderford , K. Tamura , S. Vucetic , G. Gerhard, S. Kumar


Discovering Fragile Clades And Causal Sequences In Phylogenomics By Evolutionary Sparse Learning

bioRxiv | (available)

S. Sharma, S. Kumar


R3F: An R Package for Evolutionary Dates, Rates, and Priors using Relative Rate Framework

bioRxiv | (available)

Q. Tao, S. Sharma, K. Tamura, S. Kumar


Some Mechanistic Underpinnings of Molecular Adaptations of SARS-COV-2 Spike Protein by Integrating Candidate Adaptive Polymorphisms with Protein Dynamics


N. Ose, P. Campitelli, T. Modi, I. Kazan, S. Kumar, B. Ozkan


Computational Reproducibility of Molecular Phylogenies

Molecular Biology and Evolution | 40:msad165 (9 pp)

S. Kumar, Q. Tao, A. P. Lamarca, K. Tamura


Completing a Molecular Timetree of Apes and Monkeys

Frontiers in Bioinformatics | 3:1284744 (8 pp)

J.M. Craig, G. Bamba, J. Barba, S.B. Hedges, S. Kumar


Molecular Timetrees using Relaxed Clocks and Uncertain Phylogenies

Frontiers in Bioinformatics | 3:1225807 (13 pp)

J. Barba-Montoya, S. Sharma, S. Kumar


The Origin of Eukaryotes and Rise in Complexity were Synchronous with the Rise in Oxygen

Frontiers in Bioinformatics | 3:1233281 (10 pp)

J. M. Craig, S. Kumar, S. B. Hedges


Discovering Research Articles Containing Evolutionary Timetrees by Machine Learning

Bioinformatics | 39:btad035 (7 pp)

M. Stanojevic, J. Andjelkovic, A. Kasprowicz, L.A. Huuki, J. Chao, S.B. Hedges, S. Kumar, Z. Obradovic


Improving Cellular Phylogenies through the Integrated Use of Mutation Order and Optimality Principles

Computational and Structural Biotechnology Journal | 21:3894–3903

S. Miura, T. Dolker, M. Sanderford, S. Kumar


Bootstrap Confidence for Molecular Evolutionary Estimates from Tumor Bulk Sequencing Data

Frontiers in Bioinformatics | 3:1090730 (11 pp)

J. Huzar, M. Shenoy, M. D. Sanderford, S. Kumar, S. Miura


Protein Dynamics Provide Mechanistic Insights about Epistasis among Common Missense Polymorphisms

Biophysical Journal | 122:2938–2947

N. J. Ose, P. Campitelli, R. Patel, S. Kumar, S. B. Ozkan


Gene Expression Study of Breast Cancer using Welch Satterthwaite t-test, Kaplan-Meier Estimator Plot and Huber Loss Robust Regression Model

Journal of King Saud University - Science | 35:102447 (9 pp)

S. Karim, M.S. Iqbal, N. Ahmad, M.S. Ansari, Z. Mirza, A. Merdad, S. Jastaniah, S. Kumar


Masatoshi Nei (1931–2023)

Nature Ecology & Evolution | 7:(2 pp)

J. Zhang, S. Kumar


Masatoshi Nei (1931–2023)

Molecular Biology and Evolution | 40:msad149 (5 pp)

S. Kumar, T. Gojobori


Embracing Green Computing in Molecular Phylogenetics

Molecular Biology and Evolution | 39:msac043 (4 pp)

S. Kumar


TimeTree 5: An Expanded Resource for Species Divergence Times

Molecular Biology and Evolution | 39:msac174 (6 pp)

S. Kumar, M. Suleski, J. M. Craig, A. E. Kasprowicz, M. Sanderford, M. Li, G. Stecher, S. B. Hedges


Taming the Selection of Optimal Substitution Models in Phylogenomics by Site Subsampling and Upsampling

Molecular Biology and Evolution | 39:msac236 (8 pp)

S. Sharma, S. Kumar


TopHap: Rapid Inference of Key Phylogenetic Structures from Common Haplotypes in Large Genome Collections with Limited Diversity

Bioinformatics | 38:2719–2726

M. Caraballo-Ortiz, S. Miura, M. Sanderford, T. Dolker, Q. Tao, S. Weaver, S. L. K. Pond, S. Kumar


Epistasis Creates Invariant Sites and Modulates the Rate of Molecular Evolution

Molecular Biology and Evolution | 39:msac106 (11 pp)

R. Patel, V. Carnevale, S. Kumar


Dynamic Coupling of Residues within Proteins as a Mechanistic Foundation of Many Enigmatic Pathogenic Missense Variants

PLoS Computational Biology | 18:e1010006 (22 pp)

N. J. Ose, B. M. Butler, A. Kumar, M. Sanderford, S. Kumar, S. B. Ozkan


Limitations of Phylogenomic Data Can Drive Inferred Speciation Rate Shifts

Molecular Biology and Evolution | 39:msac038 (11 pp)

J. M. Craig, S. Kumar, S. B. Hedges


Storyboarding for Biology: An Authentic STEAM Experience

The American Biology Teacher | 84:328–335

C. Babaian, S. Kumar


Epistasis Storyboarded

The American Biology Teacher | 84:562–569

C. Babaian, S. Kumar


Clone Phylogenetics Reveals Metastatic Tumor Migrations, Maps, and Models

Cancers | 14:4326 (13 pp)

A. Chroni, S. Miura, L. Hamilton, T. Vu, S.G. Gaffney, V. Aly, S. Karim, M. Sanderford, J.P. Townsend, S. Kumar


A Phylogenetic Approach to Study the Evolution of Somatic Mutational Processes in Cancer

Communications Biology | 5:617 (11 pp)

S. Miura, T. Vu, J. Choi, J. P. Townsend, S. Karim, S. Kumar


MOCA for Integrated Analysis of Gene Expression and Genetic Variation in Single Cells

Frontiers in Genetics | 13:831040 (8 pp)

J. Huzar, H. Kim, S. Kumar, S. Miura


Waiting for the Truth: Is Reluctance in Accepting an Early Origin Hypothesis for SARS-CoV-2 Delaying Our Understanding of Viral Emergence?

BMJ Global Health | 7:e008386 (8 pp)

M. Canuti, S. Bianchi, O. Kolbl, S.L.K. Pond, S. Kumar, M. Gori, C. Fappani, D. Colzani, E. Borghi, G.V. Zuccotti, M.C. Raviglione, E. Tanzi, A. Amendola


Molecular Evidence for SARS-CoV-2 in Samples Collected from Patients with Morbilliform Eruptions since Late Summer 2019 in Lombardy, Northern Italy

Environmental Research | 215:113979 (9 pp)

A. Amendola, M. Canuti, S. Bianchi, S. Kumar, C. Fappani, M. Gori, D. Colzani, S. L. K. Pond, S. Miura, M. Baggeri, A. Marchi, E. Borghi, G. V. Zuccotti, M. C. Raviglione, F. Magurano, E. Tanzi


Development of "Biosearch System" for Biobank Management and Storage of Disease Associated Genetic Information

Journal of King Saud University - Science | 34:101760 (10 pp)

S. Karim, M. Al-Kharraz, Z. Mirza, H. Noureldin, H. Abusamara, N. Alganmi, A. Merdad, S. Jastaniah, S. Kumar, M. Rasool, A. Abuzenadah, M. Al-Qahtani


Evolutionary Sparse Learning for Phylogenomics

Molecular Biology and Evolution | 38:4674–4682

S. Kumar, S. Sharma


Fast and Accurate Bootstrap Confidence Limits on Genome-scale Phylogenies using Little Bootstraps

Nature Computational Science | 1:573–577

S. Sharma, S. Kumar


Tumors are Evolutionary Island-like Ecosystems

Genome Biology and Evolution | 13:evab276 (11 pp)

A. Chroni, S. Kumar


Migrations of Cancer Cells through the Lens of Phylogenetic Biogeography

Scientific Reports | 11:17184 (13 pp)

A. Chroni, S. Miura, O. Oladeinde, V. Aly, S. Kumar


Data-driven Speciation Tree Prior for Better Species Divergence Times in Calibration-poor Molecular Phylogenies

Bioinformatics | 37:i102–i110

Q. Tao, J. Barba-Montoya, S. Kumar


Epistasis Produces an Excess of Invariant Sites in Neutral Molecular Evolution

Proceedings of the National Academy of Sciences (USA) | 118:e2018767118

R. Patel and S. Kumar


MEGA11: Molecular Evolutionary Genetics Analysis Version 11

Molecular Biology and Evolution | 38:3022–3027

K. Tamura, G. Stecher, S. Kumar


Molecular Dating for Phylogenies Containing a Mix of Populations and Species by Using Bayesian and RelTime Approaches

Molecular Ecology Resources | 21:122–136

B. Mello, Q. Tao, J. Barba-Montoya, S. Kumar


How to Build a Super Predator: From Genotype to Phenotype

The American Biology Teacher | 83:138–146

C. Babaian, S. Kumar


Assessing Rapid Relaxed-Clock Methods for Phylogenomic Dating

Genome Biology and Evolution | 13:evab251 (14 pp)

J. Barba-Montoya, Q. Tao, S. Kumar


Molecular and Morphological Clocks for Estimating Evolutionary Divergence Times

BMC Ecology and Evolution | 21:83 (15 pp)

J. Barba-Montoya, Q. Tao, S. Kumar


Deep Low-Shot Learning for Biological Image Classification and Visualization from Limited Training Samples

IEEE Transactions on Neural Networks and Learning Systems | (11 pp)

L. Cai, Z. Wang, R. Kulathinal, S. Kumar, S. Ji


Common Treatment, Common Variant: Evolutionary Prediction of Functional Pharmacogenomic Variants

Journal of Personalized Medicine | 11:131 (13 pp)

L. B. Scheinfeldt, A. Brangan, D. Kusic, S. Kumar, N. Gharani


TreeMap: A Structured Approach to Fine Mapping of eQTL Variants

Bioinformatics | 37:1125–1134

L. Liu, P. Chandrashekar, B. Zeng, M. D. Sanderford, S. Kumar, G. Gibson


The Durability of Immunity against Reinfection by SARS-CoV-2: A Comparative Evolutionary Study

The Lancet Microbe | 12:e666–e675

J. P. Townsend, H. B. Hassler, Z. Wang, S. Miura, J. Singh, S. Kumar, N. Ruddle, A.P. Galvani, A. Dornburg


The Somatic Molecular Evolution of Cancer: Mutation, Selection, and Epistasis

Progress in Biophysics and Molecular Biology | 165:56–65

K. Dasari, J. A. Somarelli, S. Kumar, J. P. Townsend


PathFinder: Bayesian Inference of Clone Migration Histories in Cancer

Bioinformatics | 36:i675–i683

S. Kumar, A. Chroni, K. Tamura, M. Sanderford, O. Oladeinde, V. Aly, T. Vu, S. Miura


Efficient Methods for Dating Evolutionary Divergences

in The Molecular Evolutionary Clock (ed. Ho) [Springer] | 197–219

Q. Tao, K. Tamura, S. Kumar


Where Did SARS-CoV-2 Come From?

Molecular Biology and Evolution | 37:2463–2464

T. Leitner, S. Kumar


Molecular Evolutionary Genetics Analysis (MEGA) for macOS

Molecular Biology and Evolution | 37:1237–1239

G. Stecher, K. Tamura, S. Kumar


A New Method for Inferring Timetrees from Temporally Sampled Molecular Sequences

PLoS Computational Biology | 16:e1007046 (24 pp)

S. Miura, K. Tamura, Q. Tao, L. A. Huuki, S. L. K. Pond, J. Priest, J. Deng, S. Kumar


Reliable Confidence Intervals for RelTime Estimates of Evolutionary Divergence Times

Molecular Biology and Evolution | 37:280–290

Q. Tao, K. Tamura, B. Mello, S. Kumar


Power and Pitfalls of Computational Methods for Inferring Clone Phylogenies and Mutation Orders from Bulk Sequencing Data

Scientific Reports | 10:3498 (21 pp)

S. Miura, T. Vu, J. Deng, T. Buturla, J. Choi, S. Kumar


Relative Efficiencies of Simple and Complex Substitution Models in Estimating Divergence Times in Phylogenomics

Molecular Biology and Evolution | 37:1819–1831

Q. Tao, J. Barba-Montoya, L. A. Huuki, M. K. Durnan, S. Kumar


Using a GTR+Gamma Substitution Model for Dating Sequence Divergence when Stationarity and Time-reversibility Assumptions are Violated

Bioinformatics | 36:i884–i894

J. Barba-Montoya, Q. Tao, S. Kumar


The Bits and Bytes of Biology: Digitalization Fuels an Emerging Generative Platform for Biological Innovation

Handbook of Digital Innovation (ed. Nambisan, Lyytinen, Yoo) [Edward Elgar] | 253–265

R. J. Kulathinal, Y. Yoo, S. Kumar


Molecular Memories of a Cambrian Fossil

The American Biology Teacher | 82:586–595

C. Babaian, S. Kumar


Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats

Current Biology | 30:(18 pp)

S. J. Pyott, M. van Tuinen, L. A. Screven, K. M. Schrode, J. Bai, C. M. Barone, S. D. Price, A. Lysakowski, M. Sanderford, S. Kumar, J. Santos-Sacchi, A. M. Lauer, T. J. Park


Interactive Effect of TLR SNPs and Exposure to Sexually Transmitted Infections on Prostate Cancer Risk in Jamaican Men

The Prostate | 80:4329–4341.e4

B. Dubey, M. Jackson, C. Zeigler-Johnson, K. Devarajan, R. E. Flores-Obando, N. McFarlane-Anderson, M. Tulloch-Reid, W. Aiken, K. Kimbro, D. Reed, L. R. Kidd, D. Gibbs, S. Kumar, C. Ragin


Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity

Cell Reports | 32:(13 pp)

X. Zhou, Q. Dou, G. Fan, Q. Zhang, M. Sanderford, A. Kaya, J. Johnson, E. Karlsson, X. Tian, A. Mikhalchenko, S. Kumar, A. Seluanov, Z. Zhang, V. Gorbunova, X. Liu, and V. N. Gladyshev


Somatic Selection Distinguishes Oncogenes and Tumor Suppressor Genes

Bioinformatics | 36:1712–1717

P. Chandrashekar, N. Ahmadinejad, J. Wang, A. Sekulic, J. B. Egan, Y. W. Asmann, S. Kumar, C. Maley, L. Liu


The Role of Conformational Dynamics and Allostery in Modulating Protein Evolution

Annual Review of Biophysics | 49:267–288

P. Campitelli, T. Modi, S. Kumar, S. B. Ozkan


Molecular Biology and Evolution of Cancer: From Discovery to Action

Molecular Biology and Evolution | 37:320–326

J. A. Somarelli, H. Gardner, V. L. Cannataro, E. F. Gunady, A. M. Boddy, N. A. Johnson, J. N. Fisk, S. G. Gaffney, J. H. Chuang, S. Li, F. D. Ciccarelli, A. R. Panchenko, K. Megquier, S. Kumar, A. Dornburg, J. DeGregori, J. P. Townsend


Deep Model Based Transfer and Multi-task Learning for Biological Image Analysis

IEEE Transactions on Big Data | 6:322–333

W. Zhang, R. Li, T. Zeng, Q. Sun, S. Kumar, J. Ye, S. Ji