Laboratory of Sudhir Kumar :: All Publications



The Reliability and Stability of an Inferred Phylogenetic Tree from Empirical Data

Molecular Biology and Evolution 34:718-723

Y. Katsura, C. Stanley, S. Kumar, M. Nei


Fast and Accurate Estimates of Divergence Times From Big Data

Molecular Biology and Evolution 34:45-50

B. Mello, Q. Tao, K. Tamura, S. Kumar



e-GRASP: An Integrated Evolutionary and GRASP Resource for Exploring Disease Associations

BMC Genomics 17:8pp

S. Karim, H.F. NourEldin, H. Abusamra, N. Salem, E. Alhathli, M.D. Sanderford, L.B. Scheinfeldt, S. Kumar


Deep Model Based Transfer and Multi-Task Learning for Biological Image Analysis

Transactions on Big Data PP:13pp

W. Zhang, R. Li, T. Zeng, Q. Sun, S. Kumar, J. Ye, S. Ji


MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

Molecular Biology and Evolution 33:1870-1874

S. Kumar, G. Stecher, K. Tamura


A Molecular Evolutionary Reference for the Human Variome

Molecular Biology and Evolution 33:245-254

L. Liu, K. Tamura, M.D. Sanderford, V. Gray, S. Kumar


Advances in Time Estimation Methods for Molecular Data

Molecular Biology and Evolution 33:863-869

S. Kumar, S.B. Hedges



Deep Model Based Transfer and Multi-Task Learning for Biological Image Analysis

The 21st ACM SIGKDD International Conference on Knowledge Discovery and Data Mining 1475-1484

W. Zhang, R. Li, T. Zeng, Q. Sun, S. Kumar, J. Ye, S. Ji


Using Disease-Associated Coding Sequence Variation to Investigate Functional Compensation by Human Paralogous Proteins

Evolutionary Bioinformatics 2015:245-251

S. Miura, S. Tate, S. Kumar


A Protocol for Diagnosing the Effect of Calibration Priors on Posterior Time Estimates: A Case Study for the Cambrian Explosion of Animal Phyla

Molecular Biology and Evolution 32:1907-1912

F.U. Battistuzzi, P. Billing-Ross, O. Murillo, A. Filipski, S. Kumar


Conformational Dynamics of Nonsynonymous Variants at Protein Interfaces Reveals Disease Association

Proteins-Structure Function and Bioinformatics 83:428-435

B.M. Butler, Z.N. Gerek, S. Kumar, S.B. Ozkan


Phylogenetic Placement of Metagenomic Reads Using the Minimum Evolution Principle

BMC Genomics 2015:9 pp

A. Filipski, K. Tamura, P. Billing-Ross, O. Murillo, S. Kumar


Evolutionary Diagnosis of Non-Synonymous Variants Involved in Differential Drug Response

BMC Medical Genomics 2015:6 pp

N.Z. Gerek, L. Liu, K. Gerold, P. Biparva, E.D. Thomas, S. Kumar


Tree of Life Reveals Clock-Like Speciation and Diversification

Molecular Biology and Evolution 32:835-845

S.B. Hedges, J. Marin, M. Suleski, M. Paymer, S. Kumar


Exceptional Reduction of the Plastid Genome of Saguaro Cactus (Carnegiea Gigantea): Loss of the NDH Gene Suite and Inverted Repeat

American Journal of Botany 102:1115-1127

M. Sanderson, D. Copetti, A. Burquez, E. Bustamante, J.L.M. Charboneau, L.E. Eguiarte, S. Kumar, H.O. Lee, J. Lee, M. McMahon, K. Steele, R. Wing, T.J. Yang, D. Zwickl, M.F. Wojciechowski



Prospects for Building Large Timetrees Using Molecular Data with Incomplete Gene Coverage Among Species

Molecular Biology and Evolution 31:2542-2550

A. Filipski, O. Murillo, A. Freydenzon, K. Tamura, S. Kumar


Signatures of Natural Selection on Mutations of Residues with Multiple Posttranslational Modifications

Molecular Biology and Evolution 31:1641-1645

V.E. Gray, L. Liu, R. Nirankari, P.V. Hornbeck, S. Kumar


No Positive Selection for G Allele in a P53 Response Element in Europeans

Cell 157:1497-1499

S. Kumar, L. Liu


Proper Reporting of Predictor Performance Reply

Nature Methods 11:781-782

S. Kumar, J. Ye, L. Liu


MyFX: A Turn-Key Software for Laboratory Desktops to Analyze Spatial Patterns of Gene Expression in Drosophila Embryos

Bioinformatics 30:1319-1321

I. Montiel, C. Konikoff, B. Braun, M. Packard, S.L. Gramates, Q. Sun, J. Ye, S. Kumar


MEGA-MD: Molecular Evolutionary Genetics Analysis Software with Mutational Diagnosis of Amino Acid Variation

Bioinformatics 30:1305-1307

G. Stecher, L. Liu, M.D. Sanderford, D. Peterson, K. Tamura, S. Kumar


Automated Annotation of Developmental Stages of Drosophila Embryos in Images Containing Spatial Patterns of Expression

Bioinformatics 30:266-273

L. Yuan, C. Pan, S. Ji, M. McCutchan, Z.H. Zhou, S. J. Newfeld, S. Kumar, J. Ye


Whole-Genome Sequencing of the Snub-Nosed Monkey Provides Insights into Folivory and Evolutionary History

Nature Genetics 46:1303-1310

X. Zhou, B. Wang, Q. Pan, J. Zhang, S. Kumar, X. Sun, Z. Liu, H. Pan, Y. Lin, G. Liu, W. Zhan, M. Li, B. Ren, X. Ma, H. Ruan, C. Cheng, D. Wang, F. Shi, Y. Hui, Y. Tao, C. Zhang, P. Zhu, Z. Xiang, W. Jiang, J. Chang, H. Wang, Z. Cao, Z. Jiang, B. Li, G. Yang, C. Roos, P.A. Garber, M.W. Bruford, R. Li, M. Li



The Evolutionary History of Amino Acid Variations Mediating Increased Resistance of S-aureus Identifies Reversion Mutations in Metabolic Regulators

PLOS ONE 8:9 pp

M.D. Champion, V. Gray, C. Eberhard, S. Kumar


Structural Dynamics Flexibility Informs Function and Evolution at a Proteome Scale

Biophysical Journal 104:228A

Z.N. Gerek, S. Kumar, S.B. Ozkan


Structural Dynamics Flexibility Informs Function and Evolution at a Proteome Scale

Evolutionary Applications 6:423-433

Z.N. Gerek, S. Kumar, S.B. Ozkan


GRASP [Genomic Resource Access for Stoichioproteomics]: Comparative Explorations of the Atomic Content of 12 Drosophila Proteomes

BMC Genomics 14:14 pp

J.D.J. Gilbert, C. Acquisti, H.M. Martinson, J.J. Elser, S. Kumar, W.F. Fagan


Evolutionary Balancing Is Critical for Correctly Forecasting Disease-Associated Amino Acid Variants

Molecular Biology and Evolution 30:1252-1257

L. Liu, S. Kumar


Image-Level and Group-Level Models for Drosophila Gene Expression Pattern Annotation

BMC Bioinformatics 14:13 pp

Q. Sun, S. Muckatira, L. Yuan, S. Ji, S. Newfeld, S. Kumar, J. Ye


MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

Molecular Biology and Evolution 30:2725-2729

K. Tamura, G. Stecher, D. Peterson, A. Filipski, S. Kumar


Genome-Wide Profiling of Human Cap-Independent Translation-Enhancing Elements

Nature Methods 10:747-750

B.P. Wellensiek, A.C. Larsen, B. Stephens, K. Kukurba, K. Waern, N. Briones, L. Liu, M. Snyder, B. L. Jacobs, S. Kumar, J.C. Chaput


A Mesh Generation and Machine Learning Framework for Drosophila Gene Expression Pattern Image Analysis

BMC Bioinformatics 2013:372-381

W. Zhang, D. Feng, R. Li, A. Chernikov, N. Chrisochoides, C. Osgood, C. Konikoff, S. Newfeld, S. Kumar, S. Ji



Exploring Spatial Patterns of Gene Expression from Fruit Fly Embryogenesis on the iPhone

Bioinformatics 28:2847-2848

S. Kumar, K. Boccia, M. McCutchan, J. Ye


Sharing and Re-Use of Phylogenetic Trees (and Associated Data) to Facilitate Synthesis

BMC Research Notes 5:574

A. Stoltzfus, B. O'Meara, J. Whitacre, R. Mounce, E. L. Gillespie, S. Kumar, D.F. Rosauer, R.A. Vos


Evolutionary Meta-Analysis of Association Studies Reveals Ancient Constraints Affecting Disease Marker Discovery

Molecular Biology and Evolution 29:2087-2094

J.T. Dudley, R. Chen, M.D. Sanderford, A.J. Butte, S. Kumar


Human Genomic Disease Variants: A Neutral Evolutionary Explanation

Genome Research 22:1383-1394

J.T. Dudley, Y. Kim, L. Liu, G. J. Markov, K. Gerold, R. Chen, A.J. Butte, S. Kumar


Performance of Computational Tools in Evaluating the Functional Impact of Laboratory-Induced Amino Acid Mutations

Bioinformatics 28:2093-2096

V.E. Gray, K.R. Kukurba, S. Kumar


Comparison of Embryonic Expression Within Multigene Families Using the FlyExpress Discovery Platform Reveals More Spatial than Temporal Divergence

Developmental Dynamics 241:150-160

C. Konikoff, T.L. Karr, M. McCutchan, S.J. Newfeld, S. Kumar


Statistics and Truth in Phylogenomics

Molecular Biology and Evolution 29:457-472

S. Kumar, A.J. Filipski, F.U. Battistuzzi, S. Pond, K. Tamura


Evolutionary Diagnosis Method for Variants in Personal Exomes

Nature Methods 9:855-856

S. Kumar, M.D. Sanderford, V.E. Gray, J. Ye, L. Liu


MEGA-CC: Computing Core of Molecular Evolutionary Genetics Analysis Program for Automated and Iterative Data Analysis

Bioinformatics 28:2685-2686

S. Kumar, G. Stecher, D. Peterson, K. Tamura


Drosophila Gene Expression Pattern Annotation through Multi-Instance Multi-Label Learning

IEEE-ACM Transactions on Computational Biology and Bioinformatics 9:98-112

Y.X. Li, S. Ji, S. Kumar, J. Ye, Z.H. Zhou


Purifying Selection Modulates the Estimates of Population Differentiation and Confounds Genome-Wide Comparisons Across Single-Nucleotide Polymorphisms

Molecular Biology and Evolution 29:3617-3623

T. Maruki, S. Kumar, Y. Kim


Estimating Divergence Times in Large Molecular Phylogenies

Proceedings of the National Academy of Sciences of the United States of America 109:19333-19338

K. Tamura, F.U. Battistuzzi, P. Billing-Ross, O. Murillo, A. Filipski, S. Kumar


Learning Sparse Representations for Fruit-Fly Gene Expression Pattern Image Annotation and Retrieval

BMC Bioinformatics 13:15 pp

L. Yuan, A. Woodard, S. Ji, Y. Jiang, Z.H. Zhou, S. Kumar, J. Ye



Molecular Clock: Testing

eLS 7 pp

F.U. Battistuzzi, A. Filipski, S. Kumar


Fast and Slow Implementations of Relaxed-Clock Methods Show Similar Patterns of Accuracy in Estimating Divergence Times

Molecular Biology and Evolution 28:2439-2442

F.U. Battistuzzi, P. Billing-Ross, A. Paliwal, S. Kumar


Stoichiogenomics: the Evolutionary Ecology of Macromolecular Elemental Composition

Trends in Ecology & Evolution 26:38-44

J.J. Elser, C. Acquisti, S. Kumar


Rampant Purifying Selection Conserves Positions with Posttranslational Modifications in Human Proteins

Molecular Biology and Evolution 28:1565-1568

V.E. Gray, S. Kumar


Phylomedicine: An Evolutionary Telescope to Explore and Diagnose the Universe of Disease Mutations

Trends in Genetics 27:377-386

S. Kumar, J.T. Dudley, A. Filipski, L. Liu


TimeTree2: Species Divergence Times on the iPhone

Bioinformatics 27:2023-2024

S. Kumar, S.B. Hedges


FlyExpress: Visual Mining of Spatiotemporal Patterns for Genes and Publications in Drosophila Embryogenesis

Bioinformatics 27:3319-3320

S. Kumar, C. Konikoff, B. Van Emden, C. Busick, K.T. Davis, S. Ji, L.W. Wu, H. Ramos, T. Brody, S. Panchanathan, J. Ye, T. L. Karr, K. Gerold, M. McCutchan, S. J. Newfeld


Evolution of Modern Birds Revealed by Mitogenomics: Timing the Radiation and Origin of Major Orders

Molecular Biology and Evolution 28:1927-1942

M.A. Pacheco, F.U. Battistuzzi, M. Lentino, R.F. Aguilar, S. Kumar, A. Escalante


MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

Molecular Biology and Evolution 28:2731-2739

K. Tamura, D. Peterson, N. Peterson, G. Stecher, M. Nei, S. Kumar



Performance of Relaxed-Clock Methods in Estimating Evolutionary Divergence Times and Their Credibility Intervals

Molecular Biology and Evolution 27:1289-1300

F.U. Battistuzzi, A. Filipski, S.B. Hedges, S. Kumar


Quantitative Analysis of the Drosophila Segmentation Regulatory Network Using Pattern Generating Potentials

PLOS Biology 8:19 pp

M. Kazemian, C. Blatti, A. Richards, M. McCutchan, N. Wakabayashi-Ito, A.S. Hammonds, S.E. Celniker, S. Kumar, S.A. Wolfe, M.H. Brodsky, S. Sinha

More Reliable Estimates of Divergence Times in Pan Using Complete MtDNA Sequences and Accounting for Population Structure

Philosophical Transactions of the Royal Society B-Biological Sciences 365:3277-3288

A.C. Stone, F.U. Battistuzzi, L.S. Kubatko, G.H. Perry, Jr., E. Trudeau, H. Lin, S. Kumar


Ecological Nitrogen Limitation Shapes the DNA Composition of Plant Genomes

Molecular Biology and Evolution 26:953-956

C. Acquisti, J.J. Elser, S. Kumar


The Timetree of Life

Oxford University Press 550 pp

S.B. Hedges, S. Kumar

Methods for Incorporating the Hypermutability of CpG Dinucleotides in Detecting Natural Selection Operating at the Amino Acid Sequence Level

Genes & Genetic Systems 85:401

Y. Suzuki, T. Gojobori, S. Kumar

Signatures of Nitrogen Limitation in the Elemental Composition of the Proteins Involved in the Metabolic Apparatus

Proceedings of the Royal Society B-Biological Sciences 276:2605-2610

C. Acquisti, S. Kumar, J.J. Elser

Association of Orthodenticle with Natural Variation for Early Embryonic Patterning in Drosophila Melanogaster

Journal of Experimental Zoology Part B-Molecular and Developmental Evolution 312:841-854

L.M. Goering, P.K. Hunt, C. Heighington, C. Busick, P.S. Pennings, J. Hermisson, S. Kumar, G. Gibson

Phylogenetic Construction of 17 Bacterial Phyla by New Method and Carefully Selected Orthologs

Gene 429:59-64

T. Horiike, D. Miyata, K. Hamada, S. Saruhashi, T. Shinozawa, S. Kumar, R. Chakraborty, T. Komiyama, Y. Tateno

A Bag-of-Words Approach for Drosophila Gene Expression Pattern Annotation

BMC Bioinformatics 2009:119-135

S. Ji, Y.X. Li, Z.H. Zhou, S. Kumar, J. Ye

Drosophila Gene Expression Pattern Annotation Using Sparse Features and Term-Term Interactions

Kdd-09: 15th ACM Sigkdd Conference on Knowledge Discovery and Data Mining 407-415

S. Ji, L. Yuan, Y.X. Li, Z.H. Zhou, S. Kumar, J. Ye

Positional Conservation and Amino Acids Shape the Correct Diagnosis and Population Frequencies of Benign and Damaging Personal Amino Acid Mutations

Genome Research 19:1562-1569

S. Kumar, M.P. Suleski, G.J. Markov, S. Lawrence, A. Marco, A.J. Filipski

Relationship Between Gene Co-Expression and Sharing of Transcription Factor Binding Sites in Drosophila Melanogaster

Bioinformatics 25:2473-2477

A. Marco, C. Konikoff, T.L. Karr, S. Kumar

The Origin of Metazoa: A Transition from Temporal to Spatial Cell Differentiation

Bioessays 31:758-768

K.V. Mikhailov, A.V. Konstantinova, M.A. Nikitin, P.V. Troshin, L.Y. Rusin, V.A. Lyubetsky, Y.V. Panchin, A.P. Mylnikov, L.L. Moroz, S. Kumar, V.V. Aleoshin

Methods for Incorporating the Hypermutability of CpG Dinucleotides in Detecting Natural Selection Operating at the Amino Acid Sequence Level

Molecular Biology and Evolution 26:2275-2284

Y. Suzuki, T. Gojobori, S. Kumar


Developmental Stage Annotation of Drosophila Gene Expression Pattern images via an entire solution path for LDA

ACM Transactions on Knowledge Discovery from Data 2:21 pp

J. Ye, J. Chen, R. Janardan, S. Kumar


Encyclopedia of Data Warehousing and Mining: Biological Image Analysis via Matrix Approximation

Idea Group 166-170

J. Ye, R. Janadan, S. Kumar

Automated Annotation of Drosophila Gene Expression Patterns Using a Controlled Vocabulary

Bioinformatics 24:1881-1888

S. Ji, L. Sun, R. Jin, S. Kumar, J. Ye

MEGA: A Biologist-Centric Software for Evolutionary Analysis of DNA and Protein Sequences

Briefings in Bioinformatics 9:299-306

S. Kumar, M. Nei, J. Dudley, K. Tamura



Evolutionary Genomics and Proteomics: Detecting Molecular Signatures of Adaptive Evolution

Sinauer Associates 241-254

A. Filipski, S. Prohaska, S. Kumar

Nullomers: Really a Matter of Natural Selection?

PLOS ONE 2:1022-1025

C. Acquisti, G. Poste, D. Curtiss, S. Kumar

Evolution of Genes and Genomes on the Drosophila Phylogeny

Nature 450:203-218

A.G. Clark, M.B. Eisen, D.R. Smith, C.M. Bergman, B. Oliver, T.A. Markow, T.C. Kaufman, M. Kellis, W. Gelbart, V.N. Iyer, D.A. Pollard, T.B. Sackton, S. Kumar, et al

Lower Bounds on Multiple Sequence Alignment Using Exact 3-Way Alignment

BMC Bioinformatics 2007:140-147

C.J. Colbourn, S. Kumar

Bioinformatics Software for Biologists in the Genomics Era

Bioinformatics 23:1713-1717

S. Kumar, J. Dudley

Multiple Sequence Alignment: In Pursuit of Homologous DNA Positions

Genome Research 17:127-135

S. Kumar, A. Filipski

MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0

Molecular Biology and Evolution 24:1596-1599

K. Tamura, J. Dudley, M. Nei, S. Kumar

Constraint and Turnover in Sex-Biased Gene Expression in the Genus Drosophila

Nature 450:233-U2

Y. Zhang, D. Sturgill, M. Parisi, S. Kumar, B. Oliver


Classification of Drosophila Embryonic Developmental State Range Based on Gene Expression Pattern Images

Computational Systems Bioinformatics Conference 2006:293-298

J. Ye, J. Chen, Q. Li, S. Kumar

Codon-Based Detection of Positive Selection Can Be Biased by Heterogeneous Distribution of Polar Amino Acids Along Protein Sequences

Computational Systems Bioinformatics Conference 2006:335-340

X. Xia, S. Kumar

Signatures of Ecological Resource Availability in the Animal and Plant Proteomes

Molecular Biology and Evolution 23:1946-1951

J.J. Elser, W.F. Fagan, S. Subramanian, S. Kumar

TimeTree: A Public Knowledge-Base of Divergence Times Among Organisms

Bioinformatics 22:2971-2972

S.B. Hedges, J. Dudley, S. Kumar

Constraining Fossil Calibrations for Molecular Clocks

Bioessays 28:770-771

S.B. Hedges, S. Kumar, M. Van Tuinen

Evolutionary Anatomies of Positions and Types of Disease-Associated and Neutral Amino Acid Mutations in the Human Genome

BMC Genomics 2006:306-314

S. Subramanian, S. Kumar

Higher Intensity of Purifying Selection on > 90% of the Human Genes Revealed by the Intrinsic Replacement Mutation Rates

Molecular Biology and Evolution 23:2283-2287

S. Subramanian, S. Kumar



The Evolution of the Genome: Comparative Genomics in Eukaryotes

Elsevier Inc. 521-583

A. Filipski, S. Kumar

Maximum Likelihood Outperforms Maximum Parsimony Even When Evolutionary Rates Are Heterotachous

Molecular Biology and Evolution 22:2139-2141

S. Gadagkar, S. Kumar

Inferring Species Phylogenies from Multiple Genes: Concatenated Sequence Tree Versus Consensus Gene Tree

Journal of Experimental Zoology Part B-Molecular and Developmental Evolution 304:64-74

S. Gadagkar, M. Rosenberg, S. Kumar


Automatic Annotation Techniques for Gene Expression Images of the Fruit Fly Embryo

Visual Communications and Image Processing 2005, Pts 1-4 5960:576-583

M. Gargesha, J. Yang, B. Van Emden, S. Panchanathan, S. Kumar, S. Li, F. Pereira, H. Shum, A. Tescher

Molecular Clocks: Four Decades of Evolution

Nature Reviews Genetics 6:654-662

S. Kumar

Placing Confidence Limits on the Molecular Age of the Human-Chimpanzee Divergence

Proceedings of the National Academy of Sciences of the United States of America 102:18842-18847

S. Kumar, A. Filipski, V. Swarna, A. Walker, S.B. Hedges

Pushing Back the Expansion of Introns in Animal Genomes

Cell 123:1182-1184

S. Kumar, S.B. Hedges



Image Registration and Similarity Computation for Chicken Gene Expression Patterns

Genomic Signal Processing and Statistics 4 pp

M. Gargesha, P. Antin, B. Van Emden, S. Panchanathan, S. Kumar

MEGA3: An Integrated Software for Molecular Evolutionary Genetic Analysis and Sequence Alignment

Integrative and Comparative Biology 43:947

S. Kumar, K. Tamura, M. Nei

The Spectrum of Human Rhodopsin Disease Mutations Through the Lens of Interspecific Variation

Gene 12:107-118

A. Briscoe, C. Gaur, S. Kumar

Identifying Spatially Similar Gene Expression Patterns in Early Stage Fruit Fly Embryo Images: Binary Feature Versus Invariant Moment Digital Representations

BMC Bioinformatics 16:202-214

R. Gurunathan, B. Van Emden, S. Panchanathan, S. Kumar

Precision of Molecular Time Estimates

Trends in Genetics 20:242-247

S.B. Hedges, S. Kumar

Gene Expression Intensity Shapes Evolutionary Rates of the Proteins Encoded by the Vertebrate Genome

Genetics 168:373-381

S. Subramanian, S. Kumar

Prospects for Inferring Very Large Phylogenies by Using the Neighbor-Joining Method

Proceedings of the National Academy of Sciences of the United States of America 101:11030-11035

K. Tamura, M. Nei, S. Kumar

Temporal Patterns of Fruit Fly (Drosophila) Evolution Revealed by Mutation Clocks

Molecular Biology and Evolution 21:36-44

K. Tamura, S. Subramanian, S. Kumar


Genomic Clocks and Evolutionary Timescales

Trends in Genetics 19:200-206

S.B. Hedges, S. Kumar


Prediction of Human Epileptic Seizures Based on Optimization and Phase Changes of Brain Electrical Activity

Optimization Methods & Software 18:81-104

L. Iasemidis, P. Pardalos, D. Shiau, W. Chaovalitwongse, K. Narayanan, S. Kumar, P. Carney, J. Sackellares

Genomic Sequence of a Ranavirus (Family Iridoviridae) Associated with Salamander Mortalities in North America

Virology 316:90-103

J. Jancovich, J. Mao, V. Chinchar, C. Wyatt, S. Case, S. Kumar, G. Valente, S. Subramanian, E. Davidson, J. Collins, B. Jacobs

Quantifying the Intragenic Distribution of Human Disease Mutations

Annals of Human Genetics 67:567-579

M. Miller, J. Parker, S. Rissing, S. Kumar

Heterogeneity of Nucleotide Frequencies Among Evolutionary Lineages and Phylogenetic Inference

Molecular Biology and Evolution 20:610-621

M. Rosenberg, S. Kumar

Taxon Sampling, Bioinformatics, and Phylogenomics

Systematic Biology 52:119-124

M. Rosenberg, S. Kumar

Patterns of Transitional Mutation Biases Within and Among Mammalian Genomes

Molecular Biology and Evolution 20:988-993

M. Rosenberg, S. Subramanian, S. Kumar

Neutral Substitutions Occur at a Faster Rate in Exons than in Noncoding DNA in Primate Genomes

Genome Research 13:838-844

S. Subramanian, S. Kumar


Vertebrate Genomes Compared

Science 297:1283-1285

S.B. Hedges, S. Kumar

Measuring Conservation of Contiguous Sets of Autosomal Markers on Bovine and Porcine Genomes in Relation to the Map of the Human Genome

Genome 45:769-776

Z. Jiang, J. Melville, H. Cao, S. Kumar, A. Filipski, A. Gibbins

BEST: A Novel Computational Approach for Comparing Gene Expression Patterns from Early Stages of Drosophila Melanogaster Development

Genetics 162:2037-2047

S. Kumar, K. Jayaraman, S. Panchanathan, R. Gurunathan, A. Marti-Subirana, S. Newfeld

Mutation Rates in Mammalian Genomes

Proceedings of the National Academy of Sciences of the United States of America 99:803-808

S. Kumar, S. Subramanian

Evolutionary Distance Estimation Under Heterogeneous Substitution Pattern Among Lineages

Molecular Biology and Evolution 19:1727-1736

K. Tamura, S. Kumar



Elucidating Gene Interaction Networks based on Gene Expression Pattern Image Analysis

Proceedings of the International Conference on Biomedical Engineering 5:232-234

S. Kumar, S. Panchanathan

Does Nonneutral Evolution Shape Observed Patterns of DNA Variation in Animal Mitochondrial Genomes?

Annual Review of Genetics 2001:539-566

A. Gerber, R. Loggins, S. Kumar, T. Dowling

A Genomic Timescale for the Origin of Eukaryotes

BMC Evolutionary Biology 1:10 pp

S.B. Hedges, H. Chen, S. Kumar, D.Y.C. Wang, A.S. Thompson, H. Watanabe

Mutation and Linkage Disequilibrium in Human MtDNA

European Journal of Human Genetics 9:969-972

P. Hedrick, S. Kumar


Classification and Indexing of Gene Expression Images

Applications of Digital Image Processing Xxiv 4472:471-481

K. Jayaraman, S. Panchanathan, S. Kumar, A. Tescher

Disparity Index: A Simple Statistic to Measure and Test the Homogeneity of Substitution Patterns Between Molecular Sequences

Genetics 158:1321-1327

S. Kumar, S. Gadagkar

Determination of the Number of Conserved Chromosomal Segments Between Species

Genetics 157:1387-1395

S. Kumar, S. Gadagkar, A. Filipski, X. Gu

MEGA2: Molecular Evolutionary Genetics Analysis Software

Bioinformatics 17:1244-1245

S. Kumar, K. Tamura, I. Jakobsen, M. Nei

Understanding Human Disease Mutations Through the Use of Interspecific Genetic Variation

Human Molecular Genetics 10:2319-2328

M. Miller, S. Kumar

Incomplete Taxon Sampling Is Not a Problem for Phylogenetic Inference

Proceedings of the National Academy of Sciences of the United States of America 98:10751-10756

M. Rosenberg, S. Kumar

Traditional Phylogenetic Reconstruction Methods Reconstruct Shallow and Deep Evolutionary Relationships Equally Well

Molecular Biology and Evolution 18:1823-1827

M. Rosenberg, S. Kumar


Molecular Evolution of Rabphilin and Linkage to the 2 '-5 ' Oligoadenylate Synthetase (OAS) Locus on 12q24.1.

Faseb Journal 15:A541

G. Smith, G. Valente, S. Kumar


Efficiency of the Neighbor-Joining Method in Reconstructing Deep and Shallow Evolutionary Relationships in Large Phylogenies

Journal of Molecular Evolution 51:544-553

S. Kumar, S. Gadagkar


Questioning Evidence for Recombination in Human Mitochondrial DNA

Science 288:1931a

S. Kumar, P. Hendric, T. Dowling, M. Stoneking

Expansion and Molecular Evolution of the Interferon-Induced 2 '-5 ' Oligoadenylate Synthetase Gene Family

Molecular Biology and Evolution 17:738-750

S. Kumar, C. Mitnik, G. Valente, G. Floyd-Smith


Molecular Evolution and Phylogenetics.

Oxford University Press 333 pp

M. Nei, S. Kumar

Single Column Discrepancy and Dynamic Max-Mini Optimizations for Quickly Finding the Most Parsimonious Evolutionary Trees

Bioinformatics 16:140-151

P. Purdom, P. Bradford, K. Tamura, S. Kumar


Molecular Evolution of a Developmental Pathway: Phylogenetic Analyses of Transforming Growth Factor-Beta Family Ligands, Receptors and Smad Signal Transducers

Genetics 152:783-795

S. Newfeld, R. Wisotzkey, S. Kumar

Divergence Time Estimates For the Early History of Animal Phyla and the Origin of Plants, Animals and Fungi

Proceedings of the Royal Society B-Biological Sciences 266:163-171

D. Wang, S. Kumar, S.B. Hedges


Divergence Times of Eutherian Mammals

Science 285:2031a

S.B. Hedges, S. Kumar


A Molecular Timescale For Vertebrate Evolution

Nature 392:917-920

S. Kumar, S.B. Hedges

The Optimization Principle in Phylogenetic Analysis Tends to Give Incorrect Topologies When the Number of Nucleotides or Amino Acids Used Is Small

Proceedings of the National Academy of Sciences of the United States of America 95:12390-12397

M. Nei, S. Kumar, K. Takahashi


Evolution and Functional Diversification of the Paired Box (Pax) DNA-Binding Domains

Molecular Biology and Evolution 14:829-842

K. Balczarek, Z. Lai, S. Kumar

Tempo and Mode of Nucleotide Substitutions in GAG and ENV Gene Fragments in Human Immunodeficiency Virus Type 1 Populations with a Known Transmission History

Journal of Virology 71:4761-4770

T. Leitner, S. Kumar, J. Albert

Sequence Convergence in the Peptide-Binding Region of Primate and Rodent MBC Class Ib Molecules

Molecular Biology and Evolution 14:1035-1041

M. Yeager, S. Kumar, A. Hughes

Detection of Convergent and Parallel Evolution at the Amino Acid Sequence Level

Molecular Biology and Evolution 14:527-536

J. Zhang, S. Kumar

Small-Sample Tests of Episodic Adaptive Evolution: A Case Study of Primate Lysozymes

Molecular Biology and Evolution 14:1335-1338

J. Zhang, S. Kumar, M. Nei


Continental Breakup and the Ordinal Diversification of Birds and Mammals

Nature 381:226-229

S.B. Hedges, P. Parker, C. Sibley, S. Kumar

Patterns of Nucleotide Substitution in Mitochondrial Protein Coding Genes of Vertebrates

Genetics 143:537-548

S. Kumar

Stepwise Algorithm for Finding Minimum Evolution Trees

Molecular Biology and Evolution 13:584-593

S. Kumar

Evolution of the Hedgehog Gene Family

Genetics 142:965-972

S. Kumar, K. Balczarek, Z. Lai

Evolutionary Relationships of Eukaryotic Kingdoms

Journal of Molecular Evolution 42:183-193

S. Kumar, A. Rzhetsky

Approximate Methods for Estimating the Pattern of Nucleotide Substitution and the Variation of Substitution Rates Among Sites

Molecular Biology and Evolution 13:650-659

Z. Yang, S. Kumar


4-Cluster Analysis - A Simple Method to Test Phylogenetic Hypotheses

Molecular Biology and Evolution 12:163-167

A. Rzhetsky, S. Kumar, M. Nei

18S Ribosomal-RNA Data Indicate That Aschelminthes Are Polyphyletic in Origin and Consist of At Least 3 Distinct Clades

Molecular Biology and Evolution 12:1132-1137

B. Winnepenninckx, T. Backeljau, L. Mackey, J. Brooks, R. De Watcher, S. Kumar, J. Garey

A New Method of Inference of Ancestral Nucleotide and Amino-Acid-Sequences

Genetics 141:1641-1650

Z. Yang, S. Kumar, M. Nei


MEGA - Molecular Evolutionary Genetics Analysis Software for Microcomputers

Computer Applications in the Biosciences 10:189-191

S. Kumar, K. Tamura, M. Nei



A Guide to Molecular Evolutionary Genetics Analysis Program for Microcomputers.

Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park, Pennsylvania 140 pp

S. Kumar, K. Tamura, M. Nei


Human Origins and Analysis of Mitochondrial-DNA Sequences

Science 255:737-739

S.B. Hedges, S. Kumar, K. Tamura, M. Stoneking